Synthesis and Fungicidal Activity of the Strobilurins Containing 1,3,4-Thiodiazole Ring

doi:10.6023/cjoc201306032

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (1): 170-177.DOI: 10.6023/cjoc201306032 Previous Articles Next Articles

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含1,3,4-噻二唑杂环的甲氧基丙烯酸酯类化合物的合成与杀菌活性研究

袁小勇^a,b, 张鹭^a, 韩小强^a, 周子原^a, 杜士杰^a, 万川^a, 杨冬燕^a, 覃兆海^a

a 中国农业大学理学院北京 100193;
b 赣州师范高等专科学校赣州 341000

收稿日期:2013-07-01 修回日期:2013-09-02 发布日期:2013-09-06
通讯作者: 覃兆海 E-mail:qinzhaohai@263.net
基金资助:
国家重点基础研究发展计划（973计划，No. 2010CB126105）资助项目.

Synthesis and Fungicidal Activity of the Strobilurins Containing 1,3,4-Thiodiazole Ring

Yuan Xiaoyong^a,b, Zhang Lu^a, Han Xiaoqiang^a, Zhou Ziyuan^a, Du Shijiea^a, Wan Chuan^a, Yang Dongyan^a, Qin Zhaohai^a

a College of Science, China Agricultural University, Beijing 100193;
b Ganzhou Teachers College, Ganzhou 341000

Received:2013-07-01 Revised:2013-09-02 Published:2013-09-06
Supported by:
Project supported by the National Basic Research Program of China (973 Program, No. 2010CB126105).

1. Synthesis and Fungicidal Activity of the Strobilurins Containing 1,3,4-Thiodiazole Ring.PDF(1876KB)

Abstract

Sixteen novel strobilurins containing 1,3,4-thiodiazole ring were synthesized by multi-step reactions including acylation, alcoholysis, hydrazinolysis, nucleophilic addition, dehydration and nucleophilic substitution from initial substituted benzoic acid and their structures were characterized by ¹H NMR, IR, MS and HRMS. The results of bioassay indicated that the fungicidal activity of title compounds is better against Rhizoctonia solani Kühn and Fusarium oxysporum than Phytophthora infestans in vitro, while remarkably higher when against Colletetrichum orbiculare. Especially, compounds 5a～5c, 5g, 6a～6c displayed higer fungicidal activities than azoxystrobin, the inhibitory rate of 5g is 77.5% at the concentration of 100 μg/mL.

Key words: 1,3,4-thiodiazole, strobilurin, synthesis, fungicidal activitiy

Cite this article

Yuan Xiaoyong, Zhang Lu, Han Xiaoqiang, Zhou Ziyuan, Du Shijiea, Wan Chuan, Yang Dongyan, Qin Zhaohai. Synthesis and Fungicidal Activity of the Strobilurins Containing 1,3,4-Thiodiazole Ring[J]. Chin. J. Org. Chem., 2014, 34(1): 170-177.

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含1,3,4-噻二唑杂环的甲氧基丙烯酸酯类化合物的合成与杀菌活性研究

Synthesis and Fungicidal Activity of the Strobilurins Containing 1,3,4-Thiodiazole Ring

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