A Novel Rhodamine B Fluorescent Probe for Hg2+: Synthesis and Evaluation

doi:10.6023/cjoc201604040

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2413-2418.DOI: 10.6023/cjoc201604040 Previous Articles Next Articles

Articles

新型罗丹明B荧光探针的合成及其对Hg²⁺的识别研究

肖慧丰^a, 张敏^a, 刘杰^a, 韩志湘^b, 仰榴青^a, 吴向阳^b

a 江苏大学化学化工学院镇江 212013;
b 江苏大学环境与安全工程学院镇江 212013

收稿日期:2016-04-19 修回日期:2016-05-19 发布日期:2016-06-08
通讯作者: 张敏,E-mail:zhangmin@ujs.edu.cn;吴向阳,E-mail:wuxy@ujs.edu.cn E-mail:zhangmin@ujs.edu.cn;wuxy@ujs.edu.cn
基金资助:
江苏省自然科学基金（No.BK20140536）资助项目.

A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation

Xiao Huifeng^a, Zhang Min^a, Liu Jie^a, Han Zhixiang^b, Yang Liuqing^a, Wu Xiangyang^b

a School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013;
b School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013

Received:2016-04-19 Revised:2016-05-19 Published:2016-06-08
Supported by:
Project supported by the Natural Science Foundation of Jiangsu Province (No.BK20140536).

1. A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation.PDF(441KB)

Abstract

A novel fluorescent probe R based on rhodamine B was synthesized by the condensation of rhodamine B hydrazide and phenylglyoxal monohydrate, followed by reduction with NaBH₄, and its structure was characterized by ¹H NMR, ¹³C NMR, ESI-MS, elemental analysis, and X-ray single analysis. It exhibited very strong fluorescence responses to Hg²⁺ with remarkably high selectivity for Hg²⁺ over other metal ions. When the concentration of Hg²⁺ was in the range of 5×10^-7~2×10^-6 mol/L, there was a good linearity between the fluorescence intensity and the concentration of Hg²⁺. The fluorescence imaging experiments of Hg²⁺ in MGC-803 living cells revealed its potential application in biological system.

Key words: fluorescent probe, rhodamine B, mercury ion, cell imaging

Cite this article

Xiao Huifeng, Zhang Min, Liu Jie, Han Zhixiang, Yang Liuqing, Wu Xiangyang. A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation[J]. Chin. J. Org. Chem., 2016, 36(10): 2413-2418.

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新型罗丹明B荧光探针的合成及其对Hg²⁺的识别研究

A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation

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新型罗丹明B荧光探针的合成及其对Hg2+的识别研究