Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives

doi:10.6023/cjoc201605021

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 237-241.DOI: 10.6023/cjoc201605021 Previous Articles Next Articles

NOTE

新型4'-(N-取代-1-哌嗪基)查尔酮衍生物的合成及其抗肿瘤活性

林玉萍^a, 虎春艳^a, 郑喜^b, 王秀丽^a, 万春平^b, 毛泽伟^a

a 云南中医学院中药学院昆明 650500;
b 云南中医学院第一附属医院中心实验室昆明 650021

收稿日期:2016-05-12 修回日期:2016-06-20 发布日期:2016-07-15
通讯作者: 毛泽伟 E-mail:ydmason@163.com
基金资助:
国家自然科学基金（No. 81460624）和云南省教育厅基金（No. 2014Z119）资助项目.

Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives

Lin Yuping^a, Hu Chunyan^a, Zheng Xi^b, Wang Xiuli^a, Wan Chunping^b, Mao Zewei^a

a School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500;
b Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021

Received:2016-05-12 Revised:2016-06-20 Published:2016-07-15
Supported by:
Project supported by theNational Natural Science Foundation of China(No. 81460624) and the Foundation of Yunnan Province Department of Education(No. 2014Z119).

1. Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives.PDF(4851KB)

Abstract

With the aim of developing new potent anticancer agents,a series of novel 4'-(N-substitued-1-piperazinyl) chalcone derivatives 3a~3j have been designed and synthesized based on the structure of the chalcone by molecular hybridization.The structures were characterized by ¹H NMR,¹³C NMR and HRMS.These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines(Hela,A549 and SGC7901) by the thiazolyl blue tetrazolium bromide(MTT) assay.The result indicated that compounds 3f,3i and 3j were found to be the potent compounds against human tumor cell lines,which are to be lead compounds for further structural modifications and activity research.

Key words: chalcone, piperazine, synthesis, anti-tumor activity

Cite this article

Lin Yuping, Hu Chunyan, Zheng Xi, Wang Xiuli, Wan Chunping, Mao Zewei. Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives[J]. Chin. J. Org. Chem., 2017, 37(1): 237-241.

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新型4'-(N-取代-1-哌嗪基)查尔酮衍生物的合成及其抗肿瘤活性

Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives

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