Synthesis of Tetraphenylethylene based Amides for Detection of Copper (II) ion with High Sensitivity and Selectivity

doi:10.6023/cjoc202403043

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四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu²⁺

苏小龙^a, 李健鹏^a, 刘孟鑫^a, 邹莉^a, 杨得锁^a,*, 冯海涛^a,*

^a宝鸡文理学院化学化工学院 AIE(聚集诱导发光)研究中心宝鸡 721000

收稿日期:2024-03-27 修回日期:2024-05-23
基金资助:
国家自然科学基金项目基金(No. 52173152 和 21805002); 陕西省科技创新团队 (2022TD-36); 陕西省自然科学基金项目(2024JC-YBMS-123); 陕西省教育厅服务地方项目(23JC001).

Synthesis of Tetraphenylethylene based Amides for Detection of Copper (II) ion with High Sensitivity and Selectivity

Xiaolong Su^a, Jianpeng Li^a, Mengxin Liu^a, Li Zou^a, Desuo Yang^a,*, Hai-Tao Feng^a,*

^aAIE Research Center, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721000

Received:2024-03-27 Revised:2024-05-23
Contact: * E-mail: yangdesuo@163.com,haitaofeng907@163.com
Supported by:
National Natural Science Foundation of China (No. 52173152 and 21805002). Scientific and Technological Innovation Team of Shaanxi Province (2022TD-36) The Natural Science Basic Research Plan in Shaanxi Province of China (2024JC-YBMS-123) and Industrial Science and Technology Plan in Shaanxi Provincial Education Department (23JC001).

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Abstract

The fluorescent probe TPE-Py was designed and synthesized, and its structure was was confirmed by NMR and HRMS. The recognition properties of probe TPE-Py for metal ions have been studied through fluorescence spectrophotometry and cell imaging experiments in HeLa cells. The results showed that TPE-Py had good selectivity and sensitivity for Cu²⁺. Among various metal ions, TPE-Py only showed exclusive fluorescence turn-off sensing on Cu²⁺ in H₂O/THF (9:1, v/v). The results of cell imaging experiments showed that the probe TPE-Py could detect Cu²⁺ in llipid droplets of cells.

Key words: aggregation-induced emission, fluorescent sensor, ion recognition, cell imaging

Cite this article

Xiaolong Su, Jianpeng Li, Mengxin Liu, Li Zou, Desuo Yang, Hai-Tao Feng. Synthesis of Tetraphenylethylene based Amides for Detection of Copper (II) ion with High Sensitivity and Selectivity[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202403043.

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四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu²⁺

Synthesis of Tetraphenylethylene based Amides for Detection of Copper (II) ion with High Sensitivity and Selectivity

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四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu2+

Synthesis of Tetraphenylethylene based Amides for Detection of Copper (II) ion with High Sensitivity and Selectivity

PDF

Supporting Info.

Knowledge

Abstract

Cite this article

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References

Related Articles 15

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四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu²⁺