Synthesis of the Reducing End Fuc-Agl Fragment of Saccharomicins

doi:10.6023/cjoc202409041

Chinese Journal of Organic Chemistry ›› 2025, Vol. 45 ›› Issue (3): 945-950.DOI: 10.6023/cjoc202409041 Previous Articles Next Articles

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赛克洛霉素还原端Fuc-Agl片段的合成

符登宪^a, 许恃维^a, 孟令奎^a^,^*(), 万谦^a^,^b^,^*(), 曾静^a^,^*()

a 华中科技大学同济医学院药学院湖北省天然药物化学与资源评价重点实验室武汉 430030
b 武汉大学药学院武汉 430071

收稿日期:2024-09-28 修回日期:2024-11-14 发布日期:2024-12-19
基金资助:
国家自然科学基金(22277033); 国家自然科学基金(22077039); 国家自然科学基金(22025102); 国家自然科学基金(22177034)

Synthesis of the Reducing End Fuc-Agl Fragment of Saccharomicins

Dengxian Fu^a, Shiwei Xu^a, Lingkui Meng^a(), Qian Wan^a^,^b(), Jing Zeng^a()

a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
b School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071

Received:2024-09-28 Revised:2024-11-14 Published:2024-12-19
Contact: * E-mail: menglk@hust.edu.cn; wanqian@hust.edu.cn; zengjing0052@hust.edu.cn
Supported by:
National Natural Science Foundation of China(22277033); National Natural Science Foundation of China(22077039); National Natural Science Foundation of China(22025102); National Natural Science Foundation of China(22177034)

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Abstract

The Fuc-Agl fragment situated at the reducing terminus of saccharomicins A and B was effectively synthesized. The synthesis encompassed pivotal procedures including taurine assembly, β-glycosidic bond establishment, sulfate ester incorporation, and ultimate deprotection, all of which were executed proficiently, culminating in an aggregate yield of 42.4% across 8 sequential steps.

Key words: saccharomicins, Fuc-Agl fragment, chemical synthesis, sulfation

Cite this article

Dengxian Fu, Shiwei Xu, Lingkui Meng, Qian Wan, Jing Zeng. Synthesis of the Reducing End Fuc-Agl Fragment of Saccharomicins[J]. Chinese Journal of Organic Chemistry, 2025, 45(3): 945-950.

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References 24

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赛克洛霉素还原端Fuc-Agl片段的合成

Synthesis of the Reducing End Fuc-Agl Fragment of Saccharomicins

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