Research Progress in Asymmetric Hydrogenation of Small Ring Compounds

doi:10.6023/cjoc202603025

Abstract

Given that chiral three- and four-membered cyclic compounds are widely present as key structural units in bioactive molecules and are frequently employed as crucial intermediates in fields such as pharmaceutical development, their synthetic research holds a significant position in the realm of organic chemistry. Transition metal-catalyzed asymmetric hydrogenation reactions (including pressurized hydrogenation and transfer hydrogenation) are ideal methods for constructing chiral small ring compounds owing to their remarkable catalytic efficiency, excellent enantioselectivity, and scalability; however, various challenges exist and slow down the related development This review systematically summarizes the latest research progress in the field of asymmetric hydrogenation of small ring compounds, with a particular focus on studies related to four-membered ring substrates (such as β-lactams, cyclobutanones, cyclobutenones, and cyclobutadienones) and three-membered ring substrates (including gem-difluorocyclopropenyl esters and gem-difluorocyclopropenyl ketones).

Key words: asymmetric hydrogenation, three-membered rings, four-membered rings, enantioselectivity

Cite this article

Shuang Yang, Xinqiang Fang. Research Progress in Asymmetric Hydrogenation of Small Ring Compounds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603025.

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