Both (R)- and (S)-MeOCPh(CF3)CH2NH2 [(R)- and (S)-I] were prepared and used to amidate optically active carboxylic acids. The 1H or 19F NMR spectra of the resulting amides showed ssignificant differences. Thus, I may be used to derivatize carboxylic acids and determine their optical purities by integration of key NMR peaks.

Key words: DETERMINATION, PHENYLETHYLAMINE P, PROTON MAGNETIC RESONANCE SPECTROMETRY, METHOXY GROUP, ENANTIOMORPH, ORGANIC SYNTHESIS, PURITY, F19 NMR SPECTROMETRY, CHIRAL REAGENT, FLUOROFORM P