Synthesis of Schiff base macrocyclic tetraamines containing γ-hydroxypropyl groups

Abstract

An efficient method for the synthesis of new Schiff base macrocyclic polyamines 5 and 6 with γ-hydroxypropyl groups is described. These new compounds have been prepared by one step cyclizative condenzation reaction of aliphatic diamine monohydroperchlorates with 3,4-dihydro- 2H-pyran-5-carbaldehyde (3), and are soluble in most organic solvents. The method is very convenient and a yield of 52～55% can be obtained. without perchloric acid have given only acyclic products 7 and 8.

Key words: SYNTHESIS, AMINES, CYCLIZATION, MACROCYCLIC COMPOUNDS

CLC Number:

O621

Cite this article

WU MINGHU;FU ENQIN;DENG LIXIN;WU CHENGTAI. Synthesis of Schiff base macrocyclic tetraamines containing γ-hydroxypropyl groups[J]. Chin. J. Org. Chem., 1995, 15(3): 303-307.

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