The unusual, functionalized spiro-cyclopropane derivatives 7 containing four stereogenic centers were obtained in good yields with de≥98% via tandem double Michael addition/internal nucleophilic substitution of the chiral synthon, 5-l-menthyloxy-3-bromo-2-(5H)- furanone(4), with amino alcohol as chiral building block 3 under mild conditions. The novel chiral compounds 7 were identified on the basis of their analytcal data and spectroscopic data, such as UV, IR, ^1H NMR, ^13C NMR, MS and elementary analysis. This result can provide importnat synthetic strategy in synthesis of some complex molecules containing spiro-cyclopropane skeleton with multiple chiral centers.

Key words: AMINO ALCOHOL P, MICHAEL ADDITION REACTION, NUCLEOPHILIC REACTION, BLOCK, SPIRO COMPOUNDS, CYCLOPROPANE P, CHIRAL REAGENT, SYNTHESIS