Synthesis of Chiral Oxazolines and Their Applications in Asymmetric ReductiveReaction

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (10): 1239-1243. Previous Articles Next Articles

手性噁唑啉的合成及其在不对称还原反应中的应用

李伟杰^a, 汪波^a, 姚骏骅^b, 许遵乐^*,a

^a中山大学化学与化学工程学院广州 510275;
^b中山大学测试中心广州 510275

收稿日期:2003-11-24 修回日期:2004-03-10 接受日期:2004-04-20 发布日期:2022-09-20
基金资助:
广东省自然科学基金(No. 011179)资助项目.

Synthesis of Chiral Oxazolines and Their Applications in Asymmetric ReductiveReaction

LI Wei-Jie^a, WANG Bo^a, YAO Jun-Hua^b, XU Zun-Le^*,a

^aSchool of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275;
^bTesting Center of Zhongshan University, Guangzhou 510275

Received:2003-11-24 Revised:2004-03-10 Accepted:2004-04-20 Published:2022-09-20
Contact: * E-mail: cedc07@zsu.edu.cn

Abstract

Six novel chiral multioxazoline ligands were synthesized frommultiple acids and chiral 2-amino-1-butanol via the corresponding multi-β-hydroxylamide as successive intermediates, and their chemical structures were determined by ¹H NMR, IR, MS spectra and elemental analysis. With these novel chiral multi-oxazoline ligands, the asymmetric reductive reaction ofacetophenone in KBH₄ or NaBH₄ was preliminarily studied.

Key words: multioxazoline, chiral reagent, asymmetric reduction, synthesis

Cite this article

LI Wei-Jie, WANG Bo, YAO Jun-Hua, XU Zun-Le. Synthesis of Chiral Oxazolines and Their Applications in Asymmetric ReductiveReaction[J]. Chinese Journal of Organic Chemistry, 2004, 24(10): 1239-1243.

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手性噁唑啉的合成及其在不对称还原反应中的应用

Synthesis of Chiral Oxazolines and Their Applications in Asymmetric ReductiveReaction

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