Synthesis and Biological Evaluation of the N-Acyl-N'- solanesylpiperazine Derivatives

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (11): 1444-1447. Previous Articles Next Articles

N-酰基-N'-茄呢基哌嗪衍生物的合成及生物活性

王超杰^*, 宋金勇, 赵瑾

河南大学化学化工学院开封 475001

收稿日期:2004-02-09 修回日期:2004-04-24 接受日期:2004-05-17 发布日期:2022-09-21
通讯作者: ^* E-mail: wcjsxq@henu.edu.cn
基金资助:
河南省科技厅(Nos. 0323024000, 0311020900)和河南大学重点学科资助项目.

Synthesis and Biological Evaluation of the N-Acyl-N'- solanesylpiperazine Derivatives

WANG Chao-Jie^*, SONG Jin-Yong, ZHAO Jin

College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475001

Received:2004-02-09 Revised:2004-04-24 Accepted:2004-05-17 Published:2022-09-21

Abstract

Using solanesol as the starting material and N-solanesylpiperazine as the key intermediate, several N-acyl-N'-solanesylpiperazine derivatives (4a～4d) and two similar compounds containing glucosyl fragments, N-(2-acetyl glucosylbenzoyl)-N'-solanesylpiperazine (5) and N-(2-glucosylbenzoyl)-N'-solanesyl piperazine (6), were firstly designed and synthesized to evaluate their biological property. Thestructure of these compounds was confirmed by IR, ¹H NMR, MS spectra and elemental analysis. Compounds 4c, 5, 6 were tested in vitro for their anti-tumor activity on KB, Bel-7402 and HCT-8 cells. The preliminary biological studies showed that compound 6 had better inhibition effect than 4c and 5 on the tested three cell lines.

Key words: solanesylpiperazine, N-acyl-N'-solanesylpiperazine, synthesis, bioactivity

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WANG Chao-Jie, SONG Jin-Yong, ZHAO Jin. Synthesis and Biological Evaluation of the N-Acyl-N'- solanesylpiperazine Derivatives[J]. Chinese Journal of Organic Chemistry, 2004, 24(11): 1444-1447.

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References

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N-酰基-N'-茄呢基哌嗪衍生物的合成及生物活性

Synthesis and Biological Evaluation of the N-Acyl-N'- solanesylpiperazine Derivatives

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