Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1569-1572. Previous Articles     Next Articles

水介质中2,7,7-三甲基-5-氧代-4-芳基-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯的合成

史达清*,a,b, 牟杰a, 庄启亚a, 王香善a   

  1. a徐州师范大学化学系 徐州 221116
    b江苏省药用植物生物技术重点实验室 徐州 221116
  • 收稿日期:2004-02-23 修回日期:2004-05-09 接受日期:2004-06-02 发布日期:2022-09-20
  • 基金资助:
    国家自然科学基金(No. 20074016)资助项目

Synthesis of Ethyl 2,7,7-Trimethyl-5-oxo-4-aryl-1,4,5,6,7,8- hexahydroquinoline-3-carboxylate in Water

SHI Da-Qing*,a,b, MOU Jiea, ZHUANG Qi-Yaa, WANG Xiang-Shana   

  1. aDepartment of Chemistry, Xuzhou Normal University, Xuzhou 221116
    bKey Laboratory of Biotechnology on Medical Plant of Jiangsu Province,Xuzhou 221116
  • Received:2004-02-23 Revised:2004-05-09 Accepted:2004-06-02 Published:2022-09-20
  • Contact: *E-mail: hongli@nankai.edu.cn; Fax: 022-23503510.

A series of ethyl 2,7,7-trimethyl-5-oxo-4-aryl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates were synthesized by the reaction of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate in the presence of triethylbenzylammonium chloride (TEBA) in water. Compared to the previous method, this new protocol has the advantages of high yields, inexpensive medium and environmental friendliness.

Key words: hexahydroquinoline, water, green chemistry