Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1629-1632. Previous Articles     Next Articles

新型含二硫键的环肽的合成

黄小毅, 王涛, 夏传琴, 余孝其*, 谢如刚*   

  1. 四川大学化学学院 成都 610064
  • 收稿日期:2004-03-22 修回日期:2004-05-24 接受日期:2004-06-27 发布日期:2022-09-20
  • 基金资助:
    湖南省教育厅(No. 02C465)、湖南省重点学科和湖南省普通高校学科带头人基金资助项目

Synthesis of Novel Disulfide Bond-Bearing Cyclopeptides

HUANG Xiao-Yi, WANG Tao, XIA Chuan-Qin, YU Xiao-Qi*, XIE Ru-Gang*   

  1. Department of Chemistry, Sichuan University, Chengdu 610064
  • Received:2004-03-22 Revised:2004-05-24 Accepted:2004-06-27 Published:2022-09-20
  • Contact: *E-mail: slliu@hnust.edu.cn

Novel disulfide bond-bearing cyclopeptides have been designed and synthesized by iodine oxidation of bis (S-Acm) of Boc-Glu-(Leu-Cys-OMe)-Leu-Cys-OMe and Boc-Asp-(Leu-Cys-OMe)-Leu-Cys-OMe in high dilute condition. The reaction products were identified by 1H NMR and MS spectra.

Key words: cyclopeptide, disulfide bond, synthesis