Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (2): 150-165. Previous Articles     Next Articles

铜催化交叉偶联反应研究的新进展

邓维, 刘磊, 郭庆祥*   

  1. 中国科学技术大学化学系 合肥 230026
  • 收稿日期:2003-03-19 修回日期:2003-05-19 接受日期:2003-06-30 发布日期:2022-09-20

Recent Progress in Copper-Catalyzed Cross-Coupling Reactions

DENG, Wei, LIU, Lei, GUO, Qing-Xiang*   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2003-03-19 Revised:2003-05-19 Accepted:2003-06-30 Published:2022-09-20
  • Contact: * E-mail: qxguo@ustc.edu.cn

The cross-coupling reaction of unsaturated carbonsis one of the most important methods in organic synthesis. It has been widely used in the manufactures of dyes, pharmaceuticals, polymers, and many other fine chemicals. Due to their low price and toxicity, Cu salts have recently emerged as novel catalysts in cross-coupling reactions of unsaturated carbons, whosereplacement of toxic and expensive Pd or Ni catalysts will greatly improve the chemical industry in both the economic and environmental aspects. In this reviewthe newest development of the Cu catalysts in cross-coupling reactions was summarized. C—C, C—N, C—O, C—S, as well as C—X coupling reactions were reviewed. The article also provided detail information about the effects of Cu salts, ligands and solvents on the efficiency of the cross-coupling reactions.

Key words: Cu catalyst, cross-coupling reaction, green chemistry