Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived fromCholic Acid under Microwave Irradiation

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (4): 399-402. Previous Articles Next Articles

单手性臂脱氧胆酸分子裂缝的设计与微波合成

彭游, 牟其明, 杨祖幸, 顿珠次仁, 陈淑华^*

四川大学化学学院成都 610064

收稿日期:2003-06-30 修回日期:2003-09-23 接受日期:2003-10-15 发布日期:2022-09-19
基金资助:
国家自然科学基金(No. 20272038)资助项目

Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived fromCholic Acid under Microwave Irradiation

PENG, You, MU, Qi-Ming, YANG, Zu-Xing, DUNZHU, Ci-Ren, CHEN, Shu-Hua^*

Faculty of Chemistry, Sichuan University, Chengdu 610064

Received:2003-06-30 Revised:2003-09-23 Accepted:2003-10-15 Published:2022-09-19
Contact: *E-mail: chemchensh@sina.com

Abstract

A novel type of molecular cleft with one chiral armbased on deoxycholic acid has been synthesized under microwave irradiation. Thestructures of these new receptors were characterized by ¹H NMR, IR, MS spectra and elemental analysis. Their recognition properties for neutral small moleculesand methyl esters of amino acids were investigated. The preliminary results indicate that these molecular clefts not only recognize neutral molecules, but alsoshow good enantio-selectivity for D/L-amino acid methyl esters.

Key words: deoxycholic acid, microwave irradiation, synthesis, molecular cleft

Cite this article

PENG, You, MU, Qi-Ming, YANG, Zu-Xing, DUNZHU, Ci-Ren, CHEN, Shu-Hua. Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived fromCholic Acid under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, 2004, 24(4): 399-402.

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单手性臂脱氧胆酸分子裂缝的设计与微波合成

Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived fromCholic Acid under Microwave Irradiation

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