Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (9): 1118-1121. Previous Articles     Next Articles

2-苯甲酰基-N-芳基氨基脲的合成及抑菌活性

郭佃顺   

  1. 山东师范大学化学系 济南 250014
  • 收稿日期:2003-11-10 修回日期:2004-03-16 接受日期:2004-04-12 发布日期:2022-09-20
  • 基金资助:
    山东省自然科学基金(No.Y2000B05)资助项目.

Synthesis and Antibacterial Activities of 2-Benzoyl-N-aryl Hydrazinecarboxamides

GUO Dian-Shun   

  1. Department of Chemistry, Shandong Normal University, Jinan 250014
  • Received:2003-11-10 Revised:2004-03-16 Accepted:2004-04-12 Published:2022-09-20
  • Contact: * E-mail: chguods@yahoo.com

Eight 2-benzoyl-N-arylhydrazinecarboxamides (PhCONHNHCONHAr) (Ar=2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 3,4-Cl2C6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4,2,4-Me2C6H3) have been synthesized via the reaction of N-substitutedtrichloroacetamides with benzoylhydrazine mediated by NaOH and characterized byelemental analyses, 1H NMR and IR spectra. The biological test shows thatsome compounds have displayed significant antibacterial activities against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

Key words: substituted hydrazinecarboxamide, trichloroacetamide, synthesis, characterization, antibacterial activity