Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (03): 308-312. Previous Articles     Next Articles

Original Articles

新型氮芥和卤代烷基哌嗪芳香醛的合成

郭灿城*,李可来,童荣标,陈亮,张晓兵   

  1. (湖南大学化学化工学院 长沙 410082)
  • 收稿日期:2004-01-12 修回日期:2004-02-29 发布日期:2005-02-28
  • 通讯作者: 郭灿城

Synthesis of New Aromatic Aldehydes Bearing Nitrogen Mustard Derivatives and Halogenoalkylpiperazinyl

GUO Can-Cheng*,LI Ke-Lai,TONG Rong-Biao,CHEN Liang,ZHANG Xiao-Bing   

  1. (College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
  • Received:2004-01-12 Revised:2004-02-29 Published:2005-02-28
  • Contact: GUO Can-Cheng

Modifications of alkylation, chlorination and Vilsmeier reaction were employed for the synthesis of aromatic aldehydes bearing nitrogen mustard derivatives and halogenoalkylpiperazinyl. Thus seven new aromatic aldehydes were synthesized from commercially available aniline and phenylpiperazine by the modified method. All of the desired compounds were characterized by MS, IR, 1H NMR spectra and elemental analysis.

Key words: aromatic aldehyde, nitrogen mustard, Vilsmeier reaction, piperazine, synthesis