Synthesis of Chiral Peptide Nucleic Acid Monomers ContainingSerine and Histidine Residues

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (08): 977-981. Previous Articles Next Articles

Original Articles

含丝氨酸和组氨酸残基手性肽核酸单体的合成

孟庆国，褚征，刘克良*

(¹军事医学科学院毒物药物研究所北京 100850)
(²烟台大学药学院烟台 264005)

收稿日期:2004-03-29 修回日期:2005-04-19 发布日期:2005-07-30
通讯作者: 刘克良

Synthesis of Chiral Peptide Nucleic Acid Monomers ContainingSerine and Histidine Residues

MENG Qing-Guo,CHU Zheng,LIU Ke-Liang*

(¹ Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)
(² School of Pharmacy, Yantai University, Yantai 264005)

Received:2004-03-29 Revised:2005-04-19 Published:2005-07-30
Contact: LIU Ke-Liang

Abstract

A chiral peptide nucleic acid (PNA) monomer containing histidine residue and thymine has been designed and synthesized employing 2,4-dinitrofluorobenzene to protect the NH group of imidazole. Other two PNA monomers containing serine and histidine residues and adenine have been prepared with the modified method to literatures. These compounds could be used as building blocks for chiral peptide nucleic acid analogues.

Key words: peptide nucleic acid, serine, synthesis, histidine, PNA monomer

Cite this article

MENG Qing-Guo,CHU Zheng,LIU Ke-Liang*. Synthesis of Chiral Peptide Nucleic Acid Monomers ContainingSerine and Histidine Residues[J]. Chin. J. Org. Chem., 2005, 25(08): 977-981.

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含丝氨酸和组氨酸残基手性肽核酸单体的合成

Synthesis of Chiral Peptide Nucleic Acid Monomers ContainingSerine and Histidine Residues

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