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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (10): 1221-1226. Previous Articles     Next Articles

Original Articles

1-环丙基-6-氟-7-(4-酰基-1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸的合成及其抗菌活性研究

李英俊*,1，刘素娜1，许永廷1，靳焜2
彭勤纪2，王营1，张治广1   

  1. (1辽宁师范大学化学化工学院 大连 116029)
    (2大连理工大学精细化学化工重点实验室 大连 116012)
  • 收稿日期:2005-01-17 修回日期:2005-04-15 发布日期:2005-10-08
  • 通讯作者: 李英俊

Synthesis and Antibacterial Activity of 1-Cyclopropyl-6-fluoro-7-(4-acyl-1-piperazinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid

LI Ying-Jun*,1,LIU Su-Na1,XU Yong-Ting1,JIN Kun2
PENG Qin-Ji2,WANG Ying1,ZHANG Zhi-Guang1   

  1. (1School of Chemical Engineering, Liaoning Normal University, Dalian 1160290)
    (2State Key Laboratory of Fine Chemicals, Dalian University of Technol-ogy, Dalian 116012)
  • Received:2005-01-17 Revised:2005-04-15 Published:2005-10-08
  • Contact: LI Ying-Jun

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Sixteen new 1-cyclopropyl-6-fluoro-7-(4-acyl-1-piperazinyl)-1,4-dihydro-4-oxo-quinoline-3- carboxylic acids were synthesized from 1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3- carboxylic acid. The structures of the new compounds were characterized by IR, 1H NMR, 13C NMR, MS spectra and elemental analysis. Antibacterial activity tests in vitro indicated that most of the target compounds possessed relatively high inhibiting activity against Escherichia coli, but lower than ciprofloxacin and ofloxacin. The target compounds had no inhibiting activity against Pseudomonas aeruginosa.

Key words: ciprofloxacin, fluoroquinolone, synthesis, antibacterial activity