Synthesis and Characterization of Bis[(trimethylsilyl)methyl]tin Arylcarboxylates

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (10): 1298-1301. Previous Articles Next Articles

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二(三甲硅亚甲基)锡二芳香羧酸酯的合成和结构表征

林森*^,1,2，邓瑞红²，卢志强²
孙小强¹,3，汪信¹，陆路德¹

(¹南京理工大学化工学院南京 210094)
(²南昌大学化学系南昌 330047)
(³江苏工业学院常州 213016)

收稿日期:2004-11-13 修回日期:2005-04-28 发布日期:2005-10-08
通讯作者: 林森

Synthesis and Characterization of Bis[(trimethylsilyl)methyl]tin Arylcarboxylates

LIN Sen*^,1,2,DENG Rui-Hong²,LU Zhi-Qiang²
SUN Xiao-Qiang¹,3,WANG Xin¹,LU Lu-De¹

(¹School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
(²Department of Chemistry, Nanchang University, Nanchang 330047)
(³Jiangsu Polytechnic University, Changzhou 213016)

Received:2004-11-13 Revised:2005-04-28 Published:2005-10-08
Contact: LIN Sen

Abstract

Eleven bis[(trimethylsilyl)methyl]tin arylcarboxylates have been synthesized by the reaction of bis[(trimethylsilyl)methyl]tin dichloride with arylcarboxylic acids, and characterized by IR, ¹H NMR, ¹³C NMR, MS spectra and elemental analysis. The preliminary bioassay tests showed that they have a good antitumour activity in vitro against tumour cells SPC-A-1.

Key words: synthesis, structural analysis, antitumour activity, organotin compound containing silicon

Cite this article

LIN Sen*^,1,2,DENG Rui-Hong²,LU Zhi-Qiang²
SUN Xiao-Qiang^1,3,WANG Xin,LU Lu-De. Synthesis and Characterization of Bis[(trimethylsilyl)methyl]tin Arylcarboxylates[J]. Chin. J. Org. Chem., 2005, 25(10): 1298-1301.

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二(三甲硅亚甲基)锡二芳香羧酸酯的合成和结构表征

Synthesis and Characterization of Bis[(trimethylsilyl)methyl]tin Arylcarboxylates

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