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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (12): 1594-1598. Previous Articles     Next Articles

Reports

含硫代酰胺新三唑类化合物的合成、结构表征及生物活性研究

许良忠*，李伟华，李凯，秦永其，李春丽，候宝荣   

  1. (1青岛科技大学化学与分子工程学院 青岛 266042)
    (2中国海洋大学化学化工学院 青岛 266033)
    (3中国科学院海洋研究所 青岛 266071)
  • 收稿日期:2005-01-14 修回日期:2005-06-20 发布日期:2005-11-30
  • 通讯作者: 许良忠

Studies on Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing Thioamide

XU Liang-Zhong*, LI Wei-Hua, LI Kai, QIN Yong-Qi, LI Chun-Li,
HOU Bao-Rong   

  1. (1 College of Chemistry and Molecule Engineering, Qingdao University of Science and Tech-nology, Qingdao 266042)
    (2 College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266033)
    (3 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071)
  • Received:2005-01-14 Revised:2005-06-20 Published:2005-11-30
  • Contact: XU Liang-Zhong

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1966

Four novel triazole compounds containing thioamide group were designed and synthesized by using triazole, phenyl isothiocyanate and aryl ethyl ketone as raw material. Their structures were conformed by elemental analysis, 1H NMR, IR and MS spectra. The crystal structure of 1-[1-anilinothiocar-bonyl-1-(4-fluorobenzoyl)methyl]-1,2,4-trizole has been determined by X-ray diffraction analysis. The preliminary bioassays have shown that the title compounds exhibit certain antifungal activity.

Key words: 1,2,4-triazole, thioamide, synthesis, biological activitity, crystal structure