Synthesis of E-Arylidene-2,3-dihydroindol-2-one Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride Phase-transfer Catalyst

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (12): 1598-1601. Previous Articles Next Articles

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在三乙基苄基氯化铵相转移催化下水相中(E)-3-亚苄基-2,3-二氢吲哚-2-酮衍生物的合成

王香善*，曾兆森，李玉玲，史达清
屠树江，魏贤勇，宗志敏

(¹徐州师范大学化学系徐州221116)
(²中国矿业大学化学工程学院徐州221008)
(³江苏省药用植物生物技术重点实验室徐州 221116)

收稿日期:2005-02-21 修回日期:2005-06-20 发布日期:2005-11-30
通讯作者: 王香善

Synthesis of E-Arylidene-2,3-dihydroindol-2-one Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride Phase-transfer Catalyst

WANG Xiang-Shan*, ZENG Zhao-Sen, LI Yu-Ling, SHI Da-Qing,
TU Shu-Jiang, WEI Xian-Yong, ZONG Zhi-Min

(¹Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
(² School of Chemical Engineering, China University of Mining and Technol-ogy, Xuzhou 221008)
(³ Key Laboratory of Biotechnology on Medical Plant of Ji-angsu Province, Xuzhou 221116)

Received:2005-02-21 Revised:2005-06-20 Published:2005-11-30
Contact: WANG Xiang-Shan

Abstract

A series of E-arylidene-2,3-dihydroindol-2-one derivatives were synthesized from aromatic aldehyde and 2,3-dihydroindol-2-one at room temperature catalyzed by triethylbenzylammonium chloride (TEBAC) in water. This method has the advantages of mild reaction conditions, good stereoselectivity, high yields (72%～96%) and environmentally benign. The structures of the products were characterized by melting points, IR, ¹H NMR spectra and elemental analysis.

Key words: E-arylidene-1,3-dihydroindol-2-one, water, synthesis, triethylbenzylammonium chloride

Cite this article

WANG Xiang-Shan*, ZENG Zhao-Sen, LI Yu-Ling, SHI Da-Qing,
TU Shu-Jiang, WEI Xian-Yong, ZONG Zhi-Min. Synthesis of E-Arylidene-2,3-dihydroindol-2-one Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride Phase-transfer Catalyst[J]. Chin. J. Org. Chem., 2005, 25(12): 1598-1601.

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在三乙基苄基氯化铵相转移催化下水相中(E)-3-亚苄基-2,3-二氢吲哚-2-酮衍生物的合成

Synthesis of E-Arylidene-2,3-dihydroindol-2-one Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride Phase-transfer Catalyst

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