Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (9): 1057-1061. Previous Articles Next Articles

Original Articles

4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征

李鹏飞，王宝雷，马宁，王素华，李正名*

(南开大学元素有机化学研究所元素有机化学国家重点实验室天津 300071)

收稿日期:2004-08-16 修回日期:2005-03-23 发布日期:2005-08-24
通讯作者: 李正名

Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides

LI Peng-Fei,WANG Bao-Lei,MA Ning,WANG Su-Hua,LI Zheng-Ming*

(State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry,

Received:2004-08-16 Revised:2005-03-23 Published:2005-08-24
Contact: LI Zheng-Ming

Abstract

Nucleophilic reaction of phenyl (substituted pyrimidin-2-yl)-carbamate with benzenesulfonyl hydrazine in the presence of DBU or DABCO afforded the title compounds 4-(substituted pyrimidin-2-yl)-1- (substituted benzenesulfonyl)semicarbazides 5. Three organic salts 5as～5cs formed from 5 and DBU or DABCO were also obtained. Structures of 5 and their salts were determined by elemental analysis and ¹H NMR spectra. The characteristic chemical shifts of ¹H NMR of such salts were discussed.

Key words: synthesis, organic salt, sulfonyl semicarbazide

Cite this article

LI Peng-Fei,WANG Bao-Lei,MA Ning,WANG Su-Hua,LI Zheng-Ming*. Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides[J]. Chin. J. Org. Chem., 2005, 25(9): 1057-1061.

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4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征

Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides

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