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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1398-1402. Previous Articles     Next Articles

Original Articles

2-氧代-2-[(2-氯-5-吡啶甲氨基)(芳基)甲基]-4-芳基-5,5-二甲基-1,3,2-二氧膦杂环己烷的合成及其生物活性研究

孙凤梅，石德清*   

  1. (华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079)
  • 收稿日期:2005-12-20 修回日期:2006-03-20 发布日期:2006-09-19
  • 通讯作者: 石德清

Studies on the Synthesis and Biological Activities of 2-[(2-Chloro- 5-pyridylmethylamino)(aryl)methyl]-4-aryl-5,5-dimethyl-1,3,2-dioxaphosphinane 2-Oxides

SUN Feng-Mei,SHI De-Qing*   

  1. (Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemis-try,
    Central China Normal University, Wuhan 430079)
  • Received:2005-12-20 Revised:2006-03-20 Published:2006-09-19
  • Contact: SHI De-Qing

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Ten novel cyclic α-aminophosphonates containing pyridine moiety were synthesized by “one pot” Mannich-type reaction. Their structures were confirmed by 1H NMR, 31P NMR, IR, MS spectra and elemental analysis. The preliminary biological activity tests show that all of the compounds have weak insecticidal activity but they have very good herbicidal activity at the concentration of 1.0×10－4 g/mL, and some of the target compounds possess good fungicidal activity at the concentration of 5.0×10－5 g/mL .

Key words: 2-chloro-5-pyridylmethylamine, synthesis, biological activity, α-amino phosphonate