The protected p-coumaric acid was esterified with corresponding hydroxyfuroxan, and the resulted ester was deprotected and condensed with aspirin to give II₁～II₃, respectively. Treatment of p-coumaric acid with dibromoalkane, followed by esterification with aspirin offered acetylsalicyl p-coumaric acid bromoalkyl ester, and then reacted with silver nitrate to give II₄～II₇, respectively. II₈ was obtained by esterification of the protected p-coumaric acid with isosorbide mononitrate, subsequent deprotection and condensation with aspirin. II₁～II₈ were identified by MS, IR, ¹H NMR spectra and elemental analysis, and screened for in vitro and in vivo thrombosis inhibitory activities in mice and rats. Most of tested compounds are comparable to aspirin in antithrombotic activity, and II₆ is more potent than aspirin.

Key words: furoxan, antithrombotic activity, aspirin, synthesis, acetylsalicyl p-coumaric acid