Synthesis and Herbicidal Activity of N-{2-Chloro-5-[3-methyl-2,6-dioxo- 4-trifluoro-methyl-2,3-dihydropyrimidin-1(6H)-yl]phenyl} Amides

Abstract

In search of safer and more efficacious herbicidal compounds, twelve N-{2-chloro-5-[3-methyl-2,6-dioxo-4-trifluoromethyl-2,3-dihydropyrimidin-1(6H)-yl]phenyl} amides were synthesized. Their structures were confirmed by IR, ¹H NMR, LC/MS spectra and elemental analysis. Preliminary bioassay showed that most of title compounds had good herbicidal ac-tivity, for example, 7a, 7b, 7c, 7g, 7h, 7i, 7k and 7l exhibited 100% inhibition to broad-leaved weeds, such as Abutilon theophrasti and Amaranthus spinosus at active ingredient 75 g/hm².

Key words: protox, synthesis, herbicidal activity, uracil

Cite this article

HUANG Ming-Zhi*^,a,b,ZHANG Quan^a,REN Ye-Guo^b,LEI Man-Xiang^b
HUANG Lu^b,REN Jing^b,YANG Guang-Fu*^,a. Synthesis and Herbicidal Activity of N-{2-Chloro-5-[3-methyl-2,6-dioxo- 4-trifluoro-methyl-2,3-dihydropyrimidin-1(6H)-yl]phenyl} Amides[J]. Chin. J. Org. Chem., 2006, 26(11): 1539-1543.

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N-{2-氯-5-[3-甲基-2,6-二氧-4-三氟甲基-2,3-二氢嘧啶-1(6H)-基]苯基}酰胺类化合物的合成及除草活性