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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (11): 1566-1570. Previous Articles     Next Articles

Original Articles

3-芳基-1-(吡啶-3-基)-2-(1H-1,2,4-三唑-1-基)-2-丙烯-1-醇的合成及生物活性研究

刘建兵，陶伟峰，胡燕，戴红，方建新*   

  1. (南开大学元素有机化学国家重点实验室 元素有机化学研究所 天津 300071 )
  • 收稿日期:2006-01-11 修回日期:1900-01-01 发布日期:2006-10-27
  • 通讯作者: 方建新

Synthesis and Biological Activities of 3-Aryl-1-(pyridin-3-yl)-2- (1H-1,2,4-triazol-1-yl)prop-2-en-1-ol

LIU Jian-Bing,TAO Wei-Feng,HU Yan,DAI Hong,FANG Jian-Xin*   

  1. (State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2006-01-11 Revised:1900-01-01 Published:2006-10-27
  • Contact: FANG Jian-Xin

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Ten new 3-aryl-1-(pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ols were synthesized by reducing 3-aryl-1-(pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one with sodium borohydride. Their structures have been characterized by 1H NMR and elemental analysis. Bioassay showed that some of them exhibited certain biological activities.

Key words: synthesis, biological activity, pyridine, 1H-1,2,4-triazole