Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (9): 1208-1216. Previous Articles     Next Articles

Review

手性催化的环氧化物立体选择性开环反应

王磊a,b,李叶芝a,黄化民a,方唯硕*,b   

  1. (a吉林大学化学学院 长春 130023)
    (b中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2005-03-29 修回日期:1900-01-01 发布日期:2006-09-11
  • 通讯作者: 方唯硕

Catalytic Enantioselective Ring Opening of Epoxides

WANG Leia,b ,LI Ye-Zhia,HUANG Hua-Mina,FANG Wei-Shuo*,b   

  1. (a College of Chemistry, Jilin University, Changchun 130023)
    (b Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050)
  • Received:2005-03-29 Revised:1900-01-01 Published:2006-09-11
  • Contact: FANG Wei-Shuo

The enantioselective ring opening of epoxides catalyzed by chiral catalysts has emerged as an important synthetic strategy for the preparation of various optically active compounds. A variety of nucleophiles have been employed successfully in these reactions. This review summarizes the progress in the last ten years.

Key words: enantioselectivity, ring opening, kinetic resolution, epoxide