Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (03): 397-401. Previous Articles Next Articles

Original Articles

四氢苯并[4',5']噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮的合成、晶体结构及杀菌活性

任青云，贺红武*，刘建超

(华中师范大学有机合成研究所教育部农药与化学生物学重点实验室武汉 430079)

收稿日期:2006-02-20 修回日期:2006-07-28 发布日期:2007-02-13
通讯作者: 贺红武

Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

REN Qing-Yun,HE Hong-Wu*,LIU Jian-Chao

(Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Organic Synthesis,
Central China Normal University, Wuhan 430079)

Received:2006-02-20 Revised:2006-07-28 Published:2007-02-13
Contact: HE Hong-Wu

Abstract

A series of new tetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one derivatives 6 have been designed and synthesized via a tandem aza-Wittig reaction. The structures of all compounds prepared have been comfirmed by ¹H NMR, IR, EI-MS spectra, elemental analysis as well as X-ray diffraction analysis for 6c. Biological test showed that some of the target compounds displayed good fungicidal activity. For example, 6f exhibited 98% inhibition of Botrytis cinerea Pers. in 50 mg/L.

Key words: aza-Wittig reaction, synthesis, crystal structure, fungicidal activity, pyrido[4,3-d]pyrimidin

Cite this article

REN Qing-Yun,HE Hong-Wu*,LIU Jian-Chao. Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives[J]. Chin. J. Org. Chem., 2007, 27(03): 397-401.

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四氢苯并[4',5']噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮的合成、晶体结构及杀菌活性

Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives

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