Synthesis and Crystal Structure of Lappaconitine Hydrobromide

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1409-1413. Previous Articles Next Articles

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刺乌头碱氢溴酸盐的合成及晶体结构

张继^a，孙文秀^a，温慧慧^a，刘汉士^a
李红坤^a，郁开北^b，王云普*^,a

(^a西北师范大学高分子研究所兰州 730070)
(^b中国科学院成都分院分析中心成都 610041)

收稿日期:2006-08-10 修回日期:2007-03-13 发布日期:2007-10-20
通讯作者: 王云普

Synthesis and Crystal Structure of Lappaconitine Hydrobromide

ZHANG Ji^a,SUN Wen-Xiu^a,WEN Hui-Hui^a,LIU Han-Shi^a
LI Hong-Kun^a,YU Kai-Bei^b,WANG Yun-Pu*^,a

(^a Institute of Polymers, Northwest Normal University, Lanzhou 730070)
(^b Analysis and Testing Center Chengdu Branch, Chinese Academy of Sci-ences, Chengdu 610041)

Received:2006-08-10 Revised:2007-03-13 Published:2007-10-20
Contact: WANG Yun-Pu

Abstract

A method for the synthesis of lappaconitine hydrobromide by the reaction of dibromoalkyl with lappaconitine is presented. Lappaconitine hydrobromide was determined by IR, ¹³C NMR, HRMS spectra, elemental analysis and X-ray diffraction analysis. Through intermolecular hydrogen bonding, the similar super molecule netlike structure is formed. Crystal data: monoclinic, P2₁, a＝1.0619(2) nm, b＝1.2196(3) nm, c＝1.2282(2) nm, β＝90.87(1)°, V＝1.59037(54) nm³, Z＝2, D_m＝1.428 g/cm^－3, F(000)＝720.0, μ＝1.349 mm^－1. Rings A, B, C, D, E and F present boat, chair, envelope, boat, boat and envelope forms, respectively. The stereo absolute configuration of lappaconitine hydrobromide was determined as 1S,4S,5S,7S,8S, 9S,10S,11S,13R,14S,16S,17R.

Key words: absolute configuration, crystal structure, characterization, synthesis, lappaconitine hydrobromide

Cite this article

ZHANG Ji^a,SUN Wen-Xiu^a,WEN Hui-Hui^a,LIU Han-Shi^a
LI Hong-Kun^a,YU Kai-Bei^b,WANG Yun-Pu*^{,a. Synthesis and Crystal Structure of Lappaconitine Hydrobromide[J]. Chin. J. Org. Chem., 2007, 27(11): 1409-1413.}

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刺乌头碱氢溴酸盐的合成及晶体结构

Synthesis and Crystal Structure of Lappaconitine Hydrobromide

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