Synthesis and Biological Activity of 8-Substituted Flavonoids

Abstract

One 8-flavonemethyl nitrogen mustard and six 8-flavonemethyl-polyisoprenylamines were designed and synthesized. The structures of the target compounds were confirmed by ¹H NMR, mass spectra and elemental analysis. All compounds, together with the commercial drug melphalan, were tested in vitro for their inhibition on three kinds of cancer cells, K562, CHO and B16. The results demonstrated that the activity of 8-flavonemethyl nitrogen mustard was similar to that of melphalan, while N,N-bis(8-flavone- methyl)geranylamine possessed higher antitumor activity than melphalan.

Key words: synthesis, flavone, biological activity

Cite this article

ZHAO Jin^a, LIU Yang^a, ZHENG Mei-Hua^a, XIE Song-Qiang^b, WANG Chao-Jie*^,a,c. Synthesis and Biological Activity of 8-Substituted Flavonoids[J]. Chin. J. Org. Chem., 2008, 28(01): 84-88.

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