Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 432-435. Previous Articles Next Articles

Original Articles

6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性研究

杨祖幸^a，陈华^a，毕英佐^b，邹燕^a，侯太平^c，王玉良*^,a

(^a四川大学化学学院成都 610064)
(^b华南农业大学动物科学院广州 510642)
(^c四川大学生命科学学院成都 610064)

收稿日期:2007-02-22 修回日期:2007-08-20 发布日期:2008-03-18
通讯作者: 王玉良

Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate

YANG Zu-Xing^a,CHEN Hua^a,BI Ying-Zuo^b ZOU Yan^a
HOU Tai-Ping^c,WANG Yu-Liang*^,a

(^aCollege of Chemistry, Sichuan University, Chengdu 610064)
(^bCollege of Animal Science, South China Agricultural University, Guangzhou 510642)
(^cCollege of Life Science, Sichuan University, Chengdu 610064)

Received:2007-02-22 Revised:2007-08-20 Published:2008-03-18
Contact: WANG Yu-Liang

Abstract

Ten ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process has the advantages of high yield and cheap raw materials, which, thus, is convenient for the commercial production. Structures of the new compounds have been confirmed by ¹H NMR, MS, IR spectra and elemental analysis. Seven of the new compounds were chosen for the anticoccidial activity test and the result has shown that four of them have anticoccidial activity.

Key words: synthesis, anticoccidial activity, ethyl 6-(substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate

Cite this article

YANG Zu-Xing^a,CHEN Hua^a,BI Ying-Zuo^b ZOU Yan^a
HOU Tai-Ping^c,WANG Yu-Liang*^,a. Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate[J]. Chin. J. Org. Chem., 2008, 28(03): 432-435.

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6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性研究

Synthesis and Anticoccidial Activity of Ethyl 6-(Substituted phenoxy)-7-chloro-4-hydroxy-3-quinolinecarboxylate

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