Synthesis and Bioactivity of N-[5-(2-Chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino Acid Ethyl Esters

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 521-524. Previous Articles Next Articles

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N-[5-(2-氯苯基)-2-呋喃甲酰氨基硫羰基]-L-α-氨基酸乙酯的合成与生物活性测定

王庆东^a,b，薛思佳*^,a，申杰峰^a，蔡志娟^a

(^a上海师范大学生命与环境科学学院上海 200234)
(^b江苏省盐城师范学院化学化工学院盐城 224002)

收稿日期:2007-04-29 修回日期:2007-10-09 发布日期:2008-03-18
通讯作者: 薛思佳

Synthesis and Bioactivity of N-[5-(2-Chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino Acid Ethyl Esters

WANG Qing-Dong^a,b,XUE Si-Jia*^,a,SHEN Jie-Feng^a,CAI Zhi-Juan^a

(^a College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)
(^b School of Chemistry & Chemical Engineering, Yancheng Teachers Uni-versity, Yancheng 224002)

Received:2007-04-29 Revised:2007-10-09 Published:2008-03-18
Contact: XUE Si-Jia

Abstract

Nine novel N-[5-(2-chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino acid ethyl esters were designed and synthesized . The structures of all target compounds were confirmed by IR, ¹H NMR, MS spectra and elemental analysis. By MTT assay, most target compounds show the activity of restraining the proliferation of K562 cells in vitro.

Key words: 5-(2-chlorophenyl)-furan-2-carboxylic acid, acylthiourea, L-α-amino acid ester, K562 cell, synthesis

Cite this article

WANG Qing-Dong,b,XUE Si-Jia*^,a,SHEN Jie-Feng^a,CAI Zhi-Juan^a. Synthesis and Bioactivity of N-[5-(2-Chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino Acid Ethyl Esters[J]. Chin. J. Org. Chem., 2008, 28(03): 521-524.

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N-[5-(2-氯苯基)-2-呋喃甲酰氨基硫羰基]-L-α-氨基酸乙酯的合成与生物活性测定

Synthesis and Bioactivity of N-[5-(2-Chlorophenyl)-2-furamidothiocarbonyl]-L-α-amino Acid Ethyl Esters

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