Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (05): 861-864. Previous Articles     Next Articles

Reports

柔荑软珊瑚Nephthea sp.中两种具有细胞毒活性的甾醇化合物

徐石海*, 廖小建,林慧   

  1. (暨南大学化学系 广州 510632 )
  • 收稿日期:2007-08-07 修回日期:2007-10-06 发布日期:2008-05-20
  • 通讯作者: 徐石海

Two Cytotoxic Sterols from the Soft Coral Nephthea sp.

XU Shi-Hai*, LIAO Xiao-Jian, LIN Hui   

  1. (Department of Chemistry, Jinan University, Guangzhou 510632)
  • Received:2007-08-07 Revised:2007-10-06 Published:2008-05-20
  • Contact: XU Shi-Hai

Two cytotoxic sterols have been isolated from Nephthea sp. collected from Xisha islands of the South China Sea by bioassay-guided isolation. Their structures were established as 24-methylcholestan-5- ene-3β,8β-diol (1) and 24-methylenecholestan-4-ene-3β,6β-diol (2) by MS, IR, 1H NMR, 13C NMR (DEPT), HSQC and HMBC analysis. Sterol 1 is a previously unknown compound and the stereochemistry of sterol 2 has been validated by X-ray diffraction analysis for the first time. Sterol 1 exhibited cytotoxicity against BEL-7402, P388 and LOVO cells (IC50 18.0, 25.5 and 20.6 μg/mL, respectively). Sterol 2 also showed significant cytotoxicity against P388 and MCF cells (IC50 1.0 and 2.5 μg/mL, respectively).

Key words: Nephthea sp., sterol, cytotoxicity, coral