Synthesis of 2-(Un)substituted Benzamido-5-(1-phenyl-3-methyl-5- chloropyrazol-4-yl)-1,3,4-thiadiazole Derivatives under Microwave Radiation

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (11): 1989-1992. Previous Articles Next Articles

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微波辐射下合成2-(未)取代苯甲酰胺基-5-(1-苯基-3-甲基-5-氯吡唑- 4-基)-1,3,4-噻二唑衍生物

孙燕荣^a; 李燕萍^a; 糟新民^a; 刘晨江^*,a,b; 王吉德^a,b

(a 新疆大学化学化工学院石油天然气精细化工教育部重点实验室乌鲁木齐 830046)
(b 西安交通大学理学院西安 710049)

收稿日期:2007-11-06 修回日期:2008-05-06 发布日期:2008-11-18
通讯作者: 刘晨江

Synthesis of 2-(Un)substituted Benzamido-5-(1-phenyl-3-methyl-5- chloropyrazol-4-yl)-1,3,4-thiadiazole Derivatives under Microwave Radiation

SUN, Yan-Rong ^a; LI, Yan-Ping ^a;ZAO, Xin-Min ^a; LIU, Chen-Jiang^*,a,b ; WANG, Ji-De ^a,b

(a Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, College of Chemistry and
Chemical Engineering, Xinjiang University, Urumqi 830046)
(b School of Sciences, Xi’an Jiaotong University, Xi’an 710049)

Received:2007-11-06 Revised:2008-05-06 Published:2008-11-18
Contact: LIU, Chen-Jiang

Abstract

A series of novel 2-(un)substituted benzamido-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-
1,3,4-thiadiazole derivatives (3a～3j) have been synthesized by the reaction of 2-amino-5-(1-phenyl-3-
methyl-5-chloropyrazol-4-yl)-1,3,4-thiadiazole (1) with (un)substituted benzoylchlorides (2a～2j) under a microwave radiation condition and an ordinary heating condition. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra.

Key words: 1,3,4-thiadiazole, pyrazole, synthesis, microwave radiation

Cite this article

SUN, Yan-Rong ^a; LI, Yan-Ping ^a;ZAO, Xin-Min ^a; LIU, Chen-Jiang^*,a,b ; WANG, Ji-De ^a,b
. Synthesis of 2-(Un)substituted Benzamido-5-(1-phenyl-3-methyl-5- chloropyrazol-4-yl)-1,3,4-thiadiazole Derivatives under Microwave Radiation[J]. Chin. J. Org. Chem., 2008, 28(11): 1989-1992.

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微波辐射下合成2-(未)取代苯甲酰胺基-5-(1-苯基-3-甲基-5-氯吡唑- 4-基)-1,3,4-噻二唑衍生物

Synthesis of 2-(Un)substituted Benzamido-5-(1-phenyl-3-methyl-5- chloropyrazol-4-yl)-1,3,4-thiadiazole Derivatives under Microwave Radiation

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