Synthesis of Piperazine Derivatives Containing Pyridinemethyl/  Thiazolemethyl and Their Biological Activities

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (11): 2001-2006. Previous Articles Next Articles

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含吡啶(噻唑)甲基的哌嗪类化合物的合成及生物活性

李刚月^*,a; 阎圣刚^a ; 蒋山^a ; 钱旭红^*,b ; 黄青春^b; 张蓉^c

(a大连海事大学材料科学与工程系高分子材料研究所大连 116026)
(b华东理工大学化学生物学上海重点实验室上海 200237)
(c大连理工大学精细化工国家重点实验室大连 116012)

收稿日期:2008-03-04 修回日期:2008-05-23 发布日期:2008-11-18
通讯作者: 李刚月

Synthesis of Piperazine Derivatives Containing Pyridinemethyl/ Thiazolemethyl and Their Biological Activities

LI, Gang-Yue^*,a; YAN, Sheng-Gang ^a; JIANG, Shan^a; QIAN, Xu-Hong^*,b;
HUANG, Qing-Chun^b; ZHANG, Rong^c

(a Institute of Polymer Materials, Department of Materials Science and Engineering, Dalian Maritime University,
Dalian 116026)
(b Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237)
(c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012)

Received:2008-03-04 Revised:2008-05-23 Published:2008-11-18
Contact: LI, Gang-Yue

Abstract

According to the principle of combination of active groups, a series of piperazine derivatives containing pyridinemethyl/thiazolemethyl were designed and synthesized from 2-chloro-5-(chloromethyl) pyridine or 2-chloro-5-(chloromethyl)thiazole via N-alkylation and addition reactions. Some compounds showed weak herbicidal activity and insecticidal activity against Aphis fabae but good insecticidal activity against Culex pipiens, among which compound 4f exhibited 100% mortality against Culex pipiens at 50 mg/L.

Key words: synthesis, biological activity, piperazine derivative

Cite this article

LI, Gang-Yue^*,a; YAN, Sheng-Gang ^a; JIANG, Shan^a; QIAN, Xu-Hong^*,b;
HUANG, Qing-Chun^b; ZHANG, Rong^c
. Synthesis of Piperazine Derivatives Containing Pyridinemethyl/ Thiazolemethyl and Their Biological Activities[J]. Chin. J. Org. Chem., 2008, 28(11): 2001-2006.

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含吡啶(噻唑)甲基的哌嗪类化合物的合成及生物活性

Synthesis of Piperazine Derivatives Containing Pyridinemethyl/ Thiazolemethyl and Their Biological Activities

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