Synthesis of (R)-2-{[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]- methylsulfinyl}-1H-benzimidazole

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (12): 2155-2158. Previous Articles Next Articles

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(R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}- 1H-苯并咪唑的合成

徐宝财*; 刘家胜; 周雅文; 辛秀兰; 胡燕霞 ; 肖阳

(北京工商大学化学与环境工程学院北京 100037)

收稿日期:2008-04-28 修回日期:2008-06-29 发布日期:2008-12-28
通讯作者: 徐宝财

Synthesis of (R)-2-{[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]- methylsulfinyl}-1H-benzimidazole

XU, Bao-Cai*; LIU, Jia-Sheng ; ZHOU, Ya-Wen; XIN, Xiu-Lan;
HU, Yan-Xia; XIAO, Yang

(School of Chemical and Environmental Engineering, Beijing Technology & Business University, Beijing 100037)

Received:2008-04-28 Revised:2008-06-29 Published:2008-12-28
Contact: XU, Bao-Cai

Abstract

A process for synthesis of (R)-2-{[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methyl- sulfinyl}-1H-benzimidazole from 2,3-lutidine was studied. The optical purity of the product was analyzed by chiral high performance liquid chromatography (HPLC) and the enantiomeric excess value reached 99%. The structures of reaction intermediates and target product were characterized by IR, UV, MS and 1H NMR spectra.

Key words: intermediate, 2,3-lutidine, synthesis, proton pump inhibitor

Cite this article

XU, Bao-Cai*; LIU, Jia-Sheng ; ZHOU, Ya-Wen; XIN, Xiu-Lan;
HU, Yan-Xia; XIAO, Yang
. Synthesis of (R)-2-{[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]- methylsulfinyl}-1H-benzimidazole[J]. Chin. J. Org. Chem., 2008, 28(12): 2155-2158.

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(R)-2-{[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基亚硫酰基}- 1H-苯并咪唑的合成

Synthesis of (R)-2-{[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]- methylsulfinyl}-1H-benzimidazole

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