Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 459-461. Previous Articles     Next Articles

Reports

3-取代吲哚酮类化合物的合成及抗癌活性研究

肖 锋 ; 罗 宇* ; 吕 伟 汤 杰   

  1. (华东师范大学化学系药物化学研究所 上海 200062)
  • 收稿日期:2008-05-14 修回日期:2008-08-10 发布日期:2009-03-20
  • 通讯作者: 罗 宇

Synthesis and Antitumor Evaluation of 3-Substituted Indolin-2-ones

Xiao, Feng; Luo, Yu*; Lü, Wei ; Tang, Jie   

  1. (Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, Shanghai 200062)
  • Received:2008-05-14 Revised:2008-08-10 Published:2009-03-20
  • Contact: Luo, Yu

Nine novel 3-substituted indolin-2-one derivatives were designed and synthesized. Structures of all target compounds were confirmed by 1H NMR, MS, IR spectra and elemental analysis. Preliminary biological test indicated that the compounds exhibited some inhibitory activity against the HL-60 cell lines.

Key words: antitumor activity, synthesis, urea, indolin-2-one