Synthesis and Antifungal Activity of 1-Substituted  Piperidin-4-one Oxime Ether

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 454-458. Previous Articles Next Articles

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1-取代哌啶-4-酮肟醚的合成与杀菌活性测定

尹安琴^a ; 薛思佳^*,a ; 方治坤^a; 陈龙^a ; 胥杨^a

(a上海师范大学生命与环境科学学院化学系上海 200234)

收稿日期:2008-06-23 修回日期:2008-10-09 发布日期:2009-03-20
通讯作者: 薛思佳

Synthesis and Antifungal Activity of 1-Substituted Piperidin-4-one Oxime Ether

Yin, Anqin ^a; Xue, Sijia^*,a; Fang, Zhikun ^a; Chen, Long^a ; Xu, Yang^a

(College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)

Received:2008-06-23 Revised:2008-10-09 Published:2009-03-20
Contact: Xue, Sijia

Abstract

Eleven unreported 1-substitutedpiperidin-4-one oxime ethers 5a～5k were synthesized with (un)substituted benzylamines or phenethylamine as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation reactions, oximation and etherification. The structures of all newly synthesized compounds were elucidated and confirmed by elemental analysis, IR, 1H NMR and MS techniques. The preliminary antifungal activity tests show that some of the target compounds have good antifungal activities.

Key words: oxime ether, synthesis, antifungal activity, 1-substituted piperidin-4-one

Cite this article

Yin, Anqin ^a; Xue, Sijia^*,a; Fang, Zhikun ^a; Chen, Long^a ; Xu, Yang^a. Synthesis and Antifungal Activity of 1-Substituted Piperidin-4-one Oxime Ether[J]. Chin. J. Org. Chem., 2009, 29(03): 454-458.

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1-取代哌啶-4-酮肟醚的合成与杀菌活性测定

Synthesis and Antifungal Activity of 1-Substituted Piperidin-4-one Oxime Ether

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