One-Pot Synthesis of Phenyl-benzylketone Thiosemicarbazone Schiff Bases

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (02): 299-302. Previous Articles Next Articles

Notes

一锅煮法合成苯基苄基酮缩氨基硫脲

庄肃凯，贺云，张创军，高润莉，张尊听*

(陕西师范大学药用资源与天然药物化学教育部重点实验室西北濒危药材资源开发国家工程实验室
陕西师范大学化学与材料科学学院西安 710062)

收稿日期:2009-05-04 修回日期:2009-06-25 发布日期:2010-03-30
通讯作者: 张尊听 E-mail:zhangzt@snnu.edu.cn
基金资助:
国家自然科学基金（No: 20772076）和教育部科学技术研究重点项目(No.107138)

One-Pot Synthesis of Phenyl-benzylketone Thiosemicarbazone Schiff Bases

Zhuang Sukai He Yun Zhang Chuangjun Gao Runli Zhang Zunting*

(Key Laboratory of Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drug in Northwest of China, School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062)

Received:2009-05-04 Revised:2009-06-25 Published:2010-03-30

Abstract

Using natural product isoflavones and thiosemicarbazide as starting materials, ten phenyl-benzylketone thiosemicarbazone derivatives were synthesized from the solution of alkali alcohol. This method is a convenient and efficient way to the synthesis of thiosemicarbazones based on isoflavones and thiosemicarbazide, which has several advantages such as simple operation, short reaction time, mild conditions and high yields. The structures of the ten thiosemicarbazones were identified by IR, NMR spectra and elemental analysis.

Key words: isoflavone, thiosemicarbazide, thiosemicarbazone, one-pot synthesis

Cite this article

PENG Su-Kai, HE Yun, ZHANG Chuang-Jun, GAO Run-Chi, ZHANG Zun-Ting. One-Pot Synthesis of Phenyl-benzylketone Thiosemicarbazone Schiff Bases[J]. Chin. J. Org. Chem., 2010, 30(02): 299-302.

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一锅煮法合成苯基苄基酮缩氨基硫脲

One-Pot Synthesis of Phenyl-benzylketone Thiosemicarbazone Schiff Bases

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