Solvent-Free Synthesis of β-Enamino Ketones (Esters) under High-Speed Vibration Miling (HSVM) Condition

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (11): 1732-1736. Previous Articles Next Articles

Notes

无溶剂高频振荡法合成β-烯胺酮(酯)的研究

范文明，高建荣，贾建洪，韩亮，盛卫坚，李郁锦*

(浙江工业大学绿色化学合成技术国家重点实验室培育基地杭州 310032)

收稿日期:2009-10-10 修回日期:2010-04-27 发布日期:2010-06-12
通讯作者: 范文明 E-mail:fanwenming001@163.com
基金资助:
浙江省自然科学基金（No. Y407306）;国家级.国家自然科学基金

Solvent-Free Synthesis of β-Enamino Ketones (Esters) under High-Speed Vibration Miling (HSVM) Condition

FAN Wen-Ming, GAO Jian-Rong, JIA Jian-Hong, HAN Liang, SHENG Wei-Jian, LI Yu-Jin

(State Key Laboratory Breeding Base of Green Chemistry-Synthesis Techology, Zhejiang University of Technology, Hangzhou 310032)

Received:2009-10-10 Revised:2010-04-27 Published:2010-06-12
Contact: Fan Wen-Ming E-mail:fanwenming001@163.com

Abstract

A series of 18 β-enamino ketones (esters) were synthesized in 60.8%～96.5% yield via the reaction of primary amines and 1,3-dicarbonyl compounds under high-speed vibration miling (HSVM) in the absence of catalyst and solvent conditions. The advantages of this new procedure were mild reaction conditions, simple protocol, high-yields and environment-friendly. All the products were characterized by GC-MS and ¹H NMR techniques.

Key words: β-enamino ketone (ester), HSVM, solvent-free, catalyst-free

CLC Number:

O621.3

Cite this article

FAN Wen-Ming, GAO Jian-Rong, JIA Jian-Hong, HAN Liang, SHENG Wei-Jian, LI Yu-Jin. Solvent-Free Synthesis of β-Enamino Ketones (Esters) under High-Speed Vibration Miling (HSVM) Condition[J]. Chin. J. Org. Chem., 2010, 30(11): 1732-1736.

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无溶剂高频振荡法合成β-烯胺酮(酯)的研究

Solvent-Free Synthesis of β-Enamino Ketones (Esters) under High-Speed Vibration Miling (HSVM) Condition

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