Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (03): 374-378. Previous Articles Next Articles

Notes

过渡金属催化下N-取代苯基-苯并噻(噁)唑酮-3-甲酰胺的合成及其生物活性

翁建全*^,1，刘幸海^1，张国富^1，谭成侠^1，丁成荣^1，欧晓明²

(¹浙江工业大学化学工程与材料学院杭州 310032)
(²国家南方农药创制中心湖南基地长沙 410007)

收稿日期:2010-04-02 修回日期:2010-09-10 发布日期:2010-10-20
通讯作者: 翁建全 E-mail:jqweng@zjut.edu.cn
基金资助:
国家自然科学基金;浙江省自然科学基金

Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone

Weng Jianquan*^,1 Liu Xinghai¹ Zhang Guofu¹ Tan Chengxia¹ Ding Chen-grong¹ Ou Xiaoming²

(¹College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032)
(²Hunan Branch of National Southern Pesticide Research Centre, Changsha 410007)

Received:2010-04-02 Revised:2010-09-10 Published:2010-10-20
Contact: Jian-Quan Weng E-mail:jqweng@zjut.edu.cn

Abstract

In order to find new benzothiazole/benzoxazole lead compounds, 15 N-arylaminocarbonyl-2- benzothiazolinone/benzoxazolone derivatives were synthesized from a coupling reaction of 2-benzothiazolinone/benzoxazolone and aryl isocyanates catalyzed by transition-metal. Their structures were confirmed by ¹H NMR, IR, MS techniques and elemental analysis. The preliminary bioassay showed that some of them exhibited certain fungicidal and insecticidal activities. The influence of some transition-metal catalyst on the coupling reaction was studied. The results showed that the corresponding prducts were obtained in high yields in the presence of palladium catalyst under mild reaction conditions.

Key words: transition-metal-catalyzed, 2-benzothiazolinone/benzoxazolone, substituted phenyl isocy-anate, synthesis, biological activity

Cite this article

WENG Jian-Quan, LIU Xing-Hai, ZHANG Guo-Fu, TAN Cheng-Xia, DING Cheng-Rong, OU Xiao-Ming . Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone[J]. Chin. J. Org. Chem., 2011, 31(03): 374-378.

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过渡金属催化下N-取代苯基-苯并噻(噁)唑酮-3-甲酰胺的合成及其生物活性

Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone

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