Recent Development in the Synthesis of Pregabalin

Abstract

Pregabalin, a lipophlic γ-aminobutyric acid (GABA) analogue, was developed for the treatment of several central nervous system disorders including epilepsy, neuropathic pain, anxiety and social phobia. The main new synthetic methods of pregabalin are summarized according to asymmetric synthetic methodology, especially on kinetic resolution, desymmetrization reaction, asymmetric hydrogenation, asymmetric Michael addition and so on.

Key words: pregabalin, kinetic resolution, asymmetric synthesis

Cite this article

CHEN Yong-Sheng, LI Xun, CHENG Ruo-Nan, ZHAO Sheng-Yin. Recent Development in the Synthesis of Pregabalin[J]. Chin. J. Org. Chem., 2011, 31(10): 1582-1594.

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