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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (11): 1930-1933. Previous Articles     Next Articles

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N-(4-取代苯基-噻唑-2-基)香豆素类亚胺化合物的合成及抑菌活性研究

袁明月1，张冬暖1，闫红飞2，刘伟华1，李德富1，张英群*1   

  1. (1河北农业大学理学院 保定 071001)
    (2河北农业大学植物保护学院 保定 071001)
  • 收稿日期:2011-04-29 修回日期:2011-06-17 发布日期:2011-07-14
  • 通讯作者: 张英群 E-mail:yingqun0203@163.com

Synthesis and Antibacterial Activity of N-(4-Substituted phenylthiazol-2-yl)coumarins

Yuan Mingyue1 Zhang Dongnuan1 Yan Hongfei2 Liu Weihua1 Li Defu1 Zhang Yingqun*1   

  1. (1 College of Science, Agricultural University of Hebei, Baoding 071001)
    (2 College of Plant Protection, Agricultural University of Hebei, Baoding 071001)
  • Received:2011-04-29 Revised:2011-06-17 Published:2011-07-14

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Nine new N-(4-substituted phenylthiazol-2-yl)coumarins were synthesized via the condensation of aminothiourea with acetyl coumarin intermediates, which were generated by the reaction of substituted salicyladenydes with ethyl acetoacetate, and sequeutial reaction with α-bromoarylketones. These compounds exhibit good antimicrobial activities. The structures of the products were established by IR, 1H NMR and HRMS techniques.

Key words: thiosemicarbazone, N-(4-substituted phenylthiazol-2-yl) coumarins, antibacterial activity, synthesis