Synthetic study of biologically active organophosphorus compounds including aminophosphonic acids, phosphonopeptides, carbocyclic and hetereocyclic compounds bearing phosphonate moiety was reported. Based on [1, 2] asymmetric induced reaction or [1, 3] proton shift, a series of chiral aminophosphonic acids and their fluorinated derivations were resulted. Introduction of methylene 1, 1- bisphosphonic acid grouping to cyclopropane, cyclopentane as well as cyclic hexadiene usually creates powerful chelating ability of the parent molecule towarding metal ions. Thus, a group of new compounds with medicinal potentiality was reported.

Key words: PHOSPHOAMIDIC ACID, TRIFLUOMETHYL, PHOSPHORYL COMPOUNDS, HETEROCYCLIC COMPOUNDS, BIOLOGICAL ACTIVITY, ORGANO PHOSPHORUS COMPOUNDS, MOLECULAR DESIGN, SYNTHESIS