In the presence of glacial acetic acid, 4-substituted acetophenone was brominated easily to afford α-bromo-4-substituted acetophenone, which was reacted with 1,2,4-triazole in acetone to get α-(1,2,4-tria-
zole-1-yl)-4-substituted acetophenone (2). Reaction of 4-substituted benzohydrazide (1) with compound 2 gave the corresponding hydrazones 3, which could be readily converted to their congener oxadiazolines 4 in good yields by treatment with acetic anhydride. Compounds 4 were confirmed by IR, 1H NMR, MS, ele-mental analysis and single crystal X-ray diffraction.

Key words: 1,3,4-oxadiazole, synthesis, crystal structure, 1H-1,2,4-triazole