Total Synthesis of 2-Alkyl-6-methoxy-1,4-benzoquinones

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 444-449. Previous Articles Next Articles

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2-烷基-6-甲氧基-1,4-苯醌的全合成

武利强* ; 杨春广; 杨利敏 ; 杨丽娟

(新乡医学院药学院新乡 453003)

收稿日期:2008-05-04 修回日期:2008-08-18 发布日期:2009-03-20
通讯作者: 武利强

Total Synthesis of 2-Alkyl-6-methoxy-1,4-benzoquinones

Wu, Liqiang*; Yang, Chunguang; Yang, Limin; Yang, Lijuan

(School of Pharmacy, Xinxiang Medical College, Xinxiang 453003)

Received:2008-05-04 Revised:2008-08-18 Published:2009-03-20
Contact: Wu, Liqiang

Abstract

2-Alkyl-6-methoxy-1,4-benzoquinones were synthesized from 3,5-dimethoxybenzaldehyde by Grignard and oxidizing reaction to give 3,5-dimethoxyphenylalkylketones, followed by selective demethylation and Huang Minglong reduction under microwave irradiation, and Teuber oxidizing reaction in good yields. All products were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: 2-alkyl-6-methoxy-1,4-benzoquinone, Huang Minglong reduction, synthesis, microwave irradiation

Cite this article

Wu, Liqiang*; Yang, Chunguang; Yang, Limin; Yang, Lijuan. Total Synthesis of 2-Alkyl-6-methoxy-1,4-benzoquinones[J]. Chin. J. Org. Chem., 2009, 29(03): 444-449.

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2-烷基-6-甲氧基-1,4-苯醌的全合成

Total Synthesis of 2-Alkyl-6-methoxy-1,4-benzoquinones

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