Synthesis and Herbicidal Activity of 3-(Substitutedphenoxy-methyl)-6-chloropyridazines

Abstract

A series of 3-(substituted phenoxymethyl)-6-chloropyridazine derivatives were synthesized as herbicide candidates by the treatment of different phenols with 3-chloro-6-methylpyridazine in DMF cata-lyzed by K₂CO₃. The new compounds were identified by ¹H NMR, IR spectra and elemental analyses. Preliminary bioassay showed that all of them had herbicidal activity against Brassica napus and Echinochloa crusgalli at 100 mg•mL^－1. The structure-activity relationship was discussed.

Key words: synthesis, herbicidal activity, structure-activity relationship, 3-(substituted phenoxymethyl)-6-chloropyridazine

Cite this article

HU Fang-Zhong, CHANG Yong-Qiang, ZHU You-Quan
LIU Bin, ZOU Xiao-Mao*, YANG Hua-Zheng*. Synthesis and Herbicidal Activity of 3-(Substitutedphenoxy-methyl)-6-chloropyridazines[J]. Chin. J. Org. Chem., 2007, 27(05): 593-596.

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