A practical synthesis of (S)-N-Boc-α-aminopimelate starting from (S)-N-Boc-pyroglutamate in three steps including a reduction, a Wittig reaction and a hydrogenation with the overall yields of 85.1% (diester) and 86.1% (monoester) was developed. Meanwhile, a practical synthesis of (S)-N-Boc-α-aminosuberate starting from (S)-N-Boc-piperidine-2-carboxylic acid in five steps including an esterification, an oxygena-tion, a reduction, a Wittig reaction and a hydrogenation with the overall yields of 72.5% (diester) and 72.4% (monoester) was also developed.

Key words: (S)-N-Boc-α-aminosuberate, (S)-N-Boc-pyroglutamate, synthesis, (S)-N-Boc-α-aminopimelate