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Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1374-1380. Previous Articles     Next Articles

Original Articles

2-取代-3-芳基-4-噻唑啉(硫)酮衍生物的合成、晶体结构和生物活性

孙小军a,b，董卫莉a，赵卫光*,a，李正名a   

  1. (a南开大学元素有机化学国家重点实验室 农药国家工程研究中心 天津 300071)
    (b淮阴师范学院化学系 淮安 223001)
  • 收稿日期:2006-12-25 修回日期:2007-04-29 发布日期:2007-10-20
  • 通讯作者: 赵卫光

Synthesis, Crystal Structure and Biological Activities of 2-Substituted- 3-aryl-4-thiazolidinone(thiazolidinethione) Derivatives

SUN Xiao-Juna,b,DONG Wei-Lia,ZHAO Wei-Guang*,a,LI Zheng-Minga   

  1. (a National Key Laboratory of Elemento-Organic Chemistry, Pesticide National Engineering Research Center,
    Nankai University, Tianjin 300071)
    (b Department of Chemistry, Huaiyin Teachers College, Huaian 223001)
  • Received:2006-12-25 Revised:2007-04-29 Published:2007-10-20
  • Contact: ZHAO Wei-Guang

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Three series of new thiazolidinone derivatives, namely 5-arylidene-4-thiazolidinones (6a～6j), 4-thiazolidinethione (7a～7e and 8) and 4-cyanoiminothiazolidine (11a～11e and 12) were synthesized from 2-substituted-3-aryl-4-thiazolidinones (4a～4e and 5). The intermediates 4a～4e and 5 were synthesized by the condensation of aldehyde, amine and mercapto acetic acid. Their structures were characterized by elemental analysis and 1H NMR spectra, and the structure of 4b was determined by X-ray single crystal diffraction method. The preliminary bioassay showed that some title compounds exhibited certain fungicidal activities and promoting cucumber cotyledon root-formation activities.

Key words: 4-cyanoiminothiazolidine, synthesis, biological activity, crystal structure, 4-thiazolidinone